YC just released their latest Request for Startups

great indication on where they see the biggest opportunities right now.

Here is the latest list:

1. AI for Low-Pesticide Agriculture
2. AI-Native Service Companies
3. AI Personalized Medicine
4. Company Brain
5. Counter-Swarm Defense
6. Dynamic Software Interfaces
7. Electronics in Space
8. Hardware Supply Chain
9. Industrial Capabilities in Space
10. Inference Chips for Agent Workflows
11. SaaS Challengers
12. Software for Agents
13. Startups That Want to Sell to Huge Companies
14. Supply Chain 2.0 for Semiconductors
15. The AI Operating System for Companies

details here: https://www.ycombinator.com/rfs